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21 Published Studies About Neuropathy - the Data is Compelling
Anodyne® Therapy is one of the few evidence based infrared light therapy modalities on the market today. In addition to the extensive amount of published evidence on the effects of infrared therapy devices with similar wavelengths (810nm-940nm), there have been 12 published peer reviewed studies demonstrating positive effects of Anodyne® Therapy for the treatment of neuropathy symptoms. To review any of the articles below, simply click on either "abstract" or "full text pdf".

JAPMA 2002 - Symptomatic Reversal of Peripheral Neuropathy in Patients With Diabetes
Endocrine Practice 2004 - Improvement of Sensory Impairment in Patients with Peripheral Neuropathy
Diabetes Care - 2004 - Restoration of Sensation, Reduced Pain, and Improved Balance in Subjects with DPN
Journal of Geriatric PT 2004 - MIRE and Physical Therapy for PN: Influence on Sensation, Balance, and Falls
JAPMA 2005 - Improved Sensitivity in Patients with Peripheral Neuropathy
Age and Ageing 2006 - Reversal of Diabetic Peripheral Neuropathy with MIRE Decreases Falls and the Fear of Falling and Improves Activities of Daily Living in Seniors
Physical and Occupational Therapy in Geriatrics 2006 - Effectiveness of MIRE and Physical Therapy for Peripheral Neuropathy: Changes in Sensation, Pain, and Balance
Journal of Diabetes and Its Complications 2006 - Improved Foot Sensitivity and Pain Reduction in Patients with Peripheral Neuropathy After Treatment with MIRE
Practical Pain Management 2007 - Infrared Photo Energy May Reduce Neuropathic Pain

Method of Action - How Does Anodyne® Therapy Work?
The mechanism of action underlying neuropathic pain relief associated with MIRE may be due, in part, to a combination of topical heat and an increased local release of nitric oxide that has been reported using this wavelength (890nm) of near infrared light energy. The source of released nitric oxide may be endothelial cells or red blood cells, or both.

Clinical Research has linked nitric oxide with:
• Increases in local circulation
• Reduction of pain
• Reduction in inflammation
• Angiogenesis
• Collagen synthesis

Nitric oxide production is compromised in both type 1 and type 2 diabetic patients. If near infrared light is able to favorably alter local nitric oxide availability in the diabetic patient, this may improve microcirculation via an alteration of cGMP-mediated vasodilation at the site of treatment. Better blood flow may, in part, explain the symptomatic decrease in pain these patients.

Nitric oxide also appears to be able to mitigate pain via a mechanism similar to morphine, namely via nitric oxide mediated production of cGMP and phosphorylation of ATP-dependent potassium channel activity. There may be a significant analgesic effect of MIRE if local concentrations of nitric oxide are increased.

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To review more information about nitric oxide, and its role in health and diabetes - please click here.

Anodyne® Therapy Increases Local Circulation
Circulation increases to various parts of the body were measured by a Moor Scanning Laser Doppler after a 20 - 30 minute Anodyne® Therapy treatments.

Before Treatment
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Heel
After Anodyne© Treatment
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Up to 3200% increase

BEFORE TREATMENT
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Lower Back
AFTER ANODYNE© TREATMENT
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Up to 1300% increase

BEFORE TREATMENT
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Elbow
AFTER ANODYNE© TREATMENT
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Up to 1300% increase

BEFORE TREATMENT
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Knee
AFTER ANODYNE© TREATMENT
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Up to 2000% increase

Anodyne® Therapy Systems vs. Heating Pad
The following series of images compares Anodyne® Therapy treatments (infrared + topical heat) to treatment with a topical heating pad. Subjects were tested for 35 minutes, and then their circulation was measured 4 hours POST treatment. As you can see, Subject #1 (Anodyne) still had a blood flux increase of 164% 4 hours post treatment, and Subject #2 had a 45% decrease in blood flux after only 2 hours post treatment!

Anodyne© Therapy Systems
Pre scan
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Flux: 124
DELAYED POST SCAN
4 hours after Anodyne® Therapy
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Flux: 328 164% increase

HEATING PAD
Pre scan
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Flux: 158
DELAYED POST SCAN
2 hours after Heating Pad
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Flux: 87 45% decrease